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Identification and Validation of Symptom Clusters in Patients with Hepatocellular Carcinoma

Journal of Korean Academy of Nursing 2009³â 39±Ç 5È£ p.683 ~ 692
KMID : 0806120090390050683
Á¶¸í¼÷ ( Cho Myoung-Sook ) - ¼º±Õ°ü´ëÇб³ ÀÇ°ú´ëÇÐ »ï¼º¼­¿ïº´¿ø ÀÓ»ó°£È£Çб³½Ç

±ÇÀΰ¢ ( Kwon In-Gak ) - ¼º±Õ°ü´ëÇб³ ÀÇ°ú´ëÇÐ »ï¼º¼­¿ïº´¿ø ÀÓ»ó°£È£Çб³½Ç
±èÈñ¼± ( Kim Hee-Sun ) - »ï¼º¼­¿ïº´¿ø °£È£º»ºÎ
±è°æÈñ ( Kim Kyung-Hee ) - Áß¾Ó´ëÇб³ °£È£Çаú
·ùÀºÁ¤ ( Ryu Eun-Jung ) - °Ç±¹´ëÇб³ °£È£Çаú

Abstract

Purpose:The purpose of this study was to identify cancer-related symptom clusters and to validate the conceptual meanings of the revealed symptom clusters in patients with hepatocellular carcinoma.

Methods:This study was a cross-sectional survey and methodological study. Patients with hepatocellular carcinoma (N=194) were recruited from a medical center in Seoul. The 20-item Symptom Checklist was used to assess patients¡¯ symptom severity. Selected symptoms were factored using principal-axis factoring with varimax rotation. To validate the revealed symptom clusters, the statistical differences were analyzed by status of patients¡¯ performance status, Child-Pugh classification, and mood state among symptom clusters.

Results:Fatigue was the most prevalent symptom (97.4%), followed by lack of energy and stomach discomfort. Patients¡¯ symptom severity ratings fit a four-factor solution that explained 61.04% of the variance. These four factors were named pain-appetite cluster, fatigue cluster, itching-constipation cluster, and gastrointestinal cluster. The revealed symptom clusters were significantly different for patient performance status (ECOG-PSR), Child-Pugh class, anxiety, and depression.

Conclusion:Knowing these symptom clusters may help nurses to understand reasonable mechanisms for the aggregation of symptoms. Efficient symptom management of disease-related and treatment-related symptoms is critical in promoting physical and emotional status in patients with hepatocellular carcinoma.
KeyWords
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Symptom, Cluster, Hepatocellular carcinoma
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